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Patients with known hypersensitivity to erythromycin.
It should also be avoided in patients with existing liver dysfunction or who are currently receiving potentially hepatotoxic drugs.
Concurrent use of astemizole or terfenadine with erythromycin is contraindicated; Concurrent use may increase the risk of cardiotoxicity, such as torsades de pointes and ventricular tachycardia, and death.
